Even though prostatitis remains a complex, often puzzling disease, studies during the last decade have clarified many of its features. Much of the prevailing confusion concerning prostatitis is attributable is attributable to imprecise methods of diagnosis.
We measured the immunologic response of the EPS using radial immunodiffusion method in 14 bacterial prostatitis cases, 39 nonbacterial prostatitis cases and 24 normal volunteer controls.
The results obtained in this study are as follows:
1. Among the 14 cases of chronic bacterial prostatitis, gram negative bacterias were cultured from VB, and/or EPS specimens in 12 cases (85.8%) , and gram positive bacterias in 2 cases (14.2%).
2. In normal group, the mean+- S.D. of IgG, IgA and IgM an serum was 1,235+- 203.78mg/dl, 192.0 +- 50.16mg/dl, 172.0+- 32.11mg/dl respectively, in chronic bacterial prostatitis 1,171.5+- 241.O6 mg/dl, 163.1+-67.61mg/dl, 137.1+- 51.88mg/dl, in nonbacterial prostatitis 1,258.3+-313.47 mg/dl, 205.0+-78.37 mg/dl, l35.0+-48.78mg/dl. There was no significant difference among the normal control group, chronic bacterial and nonbacterial prostatitis patients.
3. In the normal group, the mean+-S.D. of lgG, IgA and IgM was 1.5+- 0.74 mg/dl 0.82+- 0.06mg/dl, 2.7+- 1.37mg/dl, in chronic bacterial prostatitis 9.1+- 6.39mg/dl, 6.1+- 5.09mg/dl, 3.3+- 1.37mg/dl, in chronic nonbacterial prostatiti 2.8+- 1.99mg/dl, 2.7+- 3.05mg/dl, 2.2+- 1.56mg/dl. The levels of IgG.
4. The ratio of IgG and IgA in prostatic secretion to immunoglobulin in serum was increased in chronic bacterial prostatitis significantly more than the normal control group(P < 0.05). and IgA in prostatic secretion were more increased in chronic bacterial prostatitis than the normal control group(P< 0.05) but there was no significant elevation of EPS immunoglobulin in non-bacterial prostatitis.(P> 0.05)
5. After antimicrobial therapy the level of IgG and IgA in prostatic secretion was progressively decreased in chronic bacterial prostatitis but there was no definite change in chronic nonbacterial prostatitis.
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